What is a possible side effect of long-term systemic steroids?

Long-term systemic steroid use is known to lead to the development of cataracts, particularly posterior subcapsular cataracts. The mechanism involves the impact of steroids on lens metabolism, leading to changes in the structure of the lens fibers. This alteration can result in clouding of the lens over time, which can significantly impair vision. The risk factors increase with the duration and dosage of steroid therapy.

While it is true that systemic steroids can cause a variety of side effects, including glaucoma, hypertension, and acne, the most direct and significant ophthalmic consequence is cataract formation. This is why cataracts are commonly recognized as a potential side effect in patients receiving prolonged steroid treatments, warranting regular eye examinations to monitor for this condition.